Best Strategies for Egg Donor Preparation: A Retrospective Analysis of a Single-Center Cohort

Abstract

Egg donation is a critical component of assisted reproductive technology, but its success hing-es on optimal donor selection and stimulation protocols. This article summarizes a retrospec-tive analysis of egg donor preparation strategies at a single fertility center. The study evalu-ated donor selection criteria, oocyte quantity and quality, the role of preimplantation genetic testing for aneuploidy (PGT-A), and the comparative efficacy and safety of different follitropin preparations. Key findings indicate that while age is a significant factor, anti-Müllerian hor-mone (AMH) is a more crucial marker for ovarian reserve. A substantial proportion of cycles experienced “unmet expectations”, highlighting the physiological variability of AMH and the importance of considering antral follicle count (AFC) in cases of discordance. The data sug-gest no statistically significant difference in oocyte quantity or quality in younger donor age groups (≤30 years). Furthermore, PGT-A did not improve live birth rates in this donor oocyte population, though it did prevent transfers in cycles with no euploid embryos. The use of fol-litropin delta demonstrated a higher safety profile in terms of ovarian hyperstimulation syn-drome (OHSS) risk. These findings underscore the need for a personalized approach to donor stimulation, with AMH as the primary guide for selection and dose determination, while also acknowledging the value of other markers and protocols.